Why the study?
Wall shear stress has been suggested as a potential biomarker in various cardiovascular diseases and can be estimated from PC-MRI, motivating the validation of a parametric sequential quantification method.
A novel parametric sequential method for MRI-based wall shear stress quantification demonstrates basic applicability in vivo, potentially aiding in cardiovascular disease assessment.
In vitro validation supports technical refinement of PC-MRI WSS methods; leaves open clinical translation pending in vivo studies.
Wall shear stress (WSS) has been suggested as a potential biomarker in various cardiovascular diseases and it can be estimated from phase-contrast Magnetic Resonance Imaging (PC-MRI) velocity measurements. We present a parametric sequential method for MRI-based WSS quantification consisting of a geometry identification and a subsequent approximation of the velocity field. This work focuses on its validation, investigating well controlled high-resolution in vitro measurements of turbulent stationary flows and physiological pulsatile flows in phantoms. Initial tests for in vivo 2D PC-MRI data of the ascending aorta of three volunteers demonstrate basic applicability of the method to in vivo.
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Shokina et al. (2020) studied this question.
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