The hormone excretion was determined in five cases of pregnancy with anencephalic foetus who also had a hypotrophia of the adrenals. The only abnormality noted in the hormone excretion pattern was the consistently low excretion of oestrogenic hormones amounting to about 1/10 of the normal pregnancy level. A possible correlation between the low oestrogen excretion and the hypotrophia of the foetal adrenals is suggested.
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Frandsen et al. (1961) studied this question.