Population
30 New Zealand white rabbits
Comparison
3.0T magnetic resonance examinations with pre… vs Histological validation using collagen volume…
Design
Preclinical, randomly divided
Follow-up
up to 9 months
Authors
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Supports ECV as fibrosis marker in diabetic models; hypothesis-generating, requiring human validation before clinical use.
In a diabetic rabbit model, extracellular volume fraction (ECV) derived from T1 mapping strongly correlates with histological myocardial fibrosis, outperforming pre- and postcontrast T1 values alone.
Zeng et al. (2016) studied this question.
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