Why the study?
Does Cdc42 regulate the restoration of endothelial barrier function after thrombin-induced disruption?
Population
Endothelial cells and mouse lung endothelium model
Comparison
Expression of the dnCdc42 mutant and exposure to… vs Control conditions
Design
Preclinical
Authors
Loading...
Cdc42 may support endothelial barrier restoration after thrombin injury; hypothesis-generating for human vascular leak syndromes.
Does Cdc42 regulate the restoration of endothelial barrier function after thrombin-induced disruption?
Cdc42 plays a critical role in restoring adherens junction-dependent endothelial cell homotypic adhesion and barrier function following inflammatory mediator-induced permeability.
Kouklis et al. (2003) studied this question.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: