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The sialyl transferase of disialoganglioside formation is depressed in mammary tumors induced in the rat by 7,12-dimethylbenz[a]anthracene. Specific activities of other glycosyltransferases of the pathway ceramide to monosialo-ganglioside are unchanged or elevated so that the ganglioside GM(1) accumulates and higher gangliosides are depressed. These findings with a solid tumor are critical to an involvement of gangliosides in the cell-surface changes of tumorigenesis.
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Keenan et al. (1973) studied this question.
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