The composition of gangliosides and their synthesis in a chemically-induced rat hepatoma cell line differ from the composition and synthesis seen in a nontumorigenic rat hepatocyte cell line. The alteration in gangliosides is characterized by a decrease in disialoceramide tetrahexoside ganglioside and an increase in monosialoceramide lactoside (hematoside) and monosialoceramide tetrahexoside. The change resembles the altered pattern of gangliosides which occurs in mouse cell lines after transformation with oncogenic DNA viruses.
No takes yet. Share an insight, caveat, or question.
Brady et al. (1969) studied this question.
Synapse has enriched 2 closely related papers on similar clinical questions. Consider them for comparative context: