Population
Shaker potassium channel (wild-type and deletion mutant)
Comparison
Deletion of the S3-S4 linker and attachment of… vs Wild-type Shaker potassium channel
Design
Preclinical
Authors
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No immediate clinical implications; leaves open whether dual voltage-sensor transitions are conserved in human cardiac Kv channels.
The study demonstrates that the voltage sensor of the Shaker potassium channel undergoes two distinct conformational changes, with the S3-S4 linker forming a large part of the protein-lined vestibule.
Sørensen et al. (2000) studied this question.
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