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THE search for effective urinary antibacterial agents is never ending. Recent reports propose dl-methionine as an effective agent for urinary antisepsis. It has been said to lower urinary pH and promote excretion of bacteriostatic substances.1 , 2 About 40 per cent of the methionine given orally has been accounted for as increased urinary sulfate. Free methionine and aminobutyric acid are also excreted in the urine.3 Escherichia coli, streptococcus, pseudomonas, proteus and staphylococcus species of common urinary pathogens have been found to metabolize and require methionine.4 5 6 7 8 The d-isomer is not utilized for growth by these bacteria. Also, d-aminobutyric acid, a metabolite of . . .
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McDonald et al. (1959) studied this question.
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