Premature Menopause, Clonal Hematopoiesis, and Coronary Artery Disease in Postmenopausal Women
Why the study?
Premature menopause is an independent risk factor for cardiovascular disease in women, but the mechanisms remain unclear, and whether it is associated with clonal hematopoiesis of indeterminate potential is unknown.
Does premature menopause increase the risk of clonal hematopoiesis of indeterminate potential (CHIP) and incident coronary artery disease in postmenopausal women?
Population
19 606 postmenopausal women from UK Biobank and Women's Health Initiative
Comparison
Premature menopause (natural or surgical before age 40 years) vs without premature menopause
Design
Observational cohort study
Authors
Discussion
Loading...
Member takes
Implication
Premature menopause was associated with CHIP; hypothesis-generating for CVD mechanisms and requires prospective validation.
Structured PICO
Does premature menopause increase the risk of clonal hematopoiesis of indeterminate potential (CHIP) and incident coronary artery disease in postmenopausal women?
P
Population
19,606 postmenopausal women from the UK Biobank (aged 40 to 70 years) and Women's Health Initiative (aged 50 to 79 years).
I
Intervention
Premature menopause (defined as natural or surgical menopause occurring before age 40 years)
C
Comparator
Postmenopausal women without a history of premature menopause
O
Outcome
Presence of any clonal hematopoiesis of indeterminate potential (CHIP) and CHIP with variant allele frequency >0.1surrogate
Premature menopause, particularly natural premature menopause, is independently associated with CHIP, providing a potential mechanistic link to increased cardiovascular disease risk in these women.
Cite This Study
Honigberg et al. (2020) studied this question.