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January 1, 1977Journal of Medical Virology

Cyclic excretion of hepatitis A virus in experimentally infected chimpanzees: Biophysical characterization of the associated HAV particles

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Population

Two chimpanzees experimentally infected with the Phoenix Antigen strain of HAV

Design

Preclinical

Follow-up

21 days postinoculation

Authors

DBDaniel W. BradleyEcological Society of AmericaCGC. R. GravelleUnited States Public Health ServiceECEdwin H. CookRoosevelt University

Discussion

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Implication

Cyclic HAV excretion patterns in chimpanzees are hypothesis-generating; leaves open relevance to human transmission or diagnostics.

Structured PICO

P
Population
Two chimpanzees experimentally infected with the Phoenix Antigen strain of HAV
I
Intervention
Experimental infection with the Phoenix Antigen strain of HAV
O
Outcome
Cyclic excretion of virus particles and biophysical characterization (buoyant densities) of HAV particlessurrogate

Experimental infection of chimpanzees with HAV results in cyclic excretion of virus particles with varying buoyant densities over time.

Cite This Study

Bradley et al. (1977) studied this question.

synapsesocial.com/papers/6a8513edde619cf7bcde12f7https://doi.org/10.1002/jmv.1890010206
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Also Consider

Synapse has enriched 4 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Comparative Study of Seven Picornaviruses of Man1966 · 29 citations
  2. 2The Relationship between a 27-nm Virus-Like Particle and Hepatitis A as Demonstrated by Immune Electron Microscopy1974 · 47 citations
  3. 3Hepatitis A: Report of a Common-Source Outbreak with Recovery of a Possible Etiologic Agent. II. Laboratory Studies1975 · 75 citations
  4. 4Preliminary Studies of Hepatitis A in Chimpanzees1975 · 54 citations