Renal function in the rat has been measured after irradiation of the left kidney with single doses of 1000, 2000, or 3000 rad of 250 kVp X rays. Effective renal plasma flow during 6 months postirradiation was estimated using [¹²³ I]hippuran and a gamma-camera with a pinhole collimator. Major renal failure was observed at 18 weeks after 2000 rad and slightly earlier after 3000 rad. The deposition of collagen was measured by estimation of the hydroxyproline content. This was increased in irradiated kidneys 20 weeks after doses of 2000 and 3000 rad. The relationship between kidney function and fibrosis is discussed.
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Chauser et al. (1976) studied this question.
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