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It has been found by several authors that the total protein in serum and the albumin-globulin ratio are decreased in animals after whole-body X-irradiation (1, 2). Recently, however, more detailed information became available about the effects of radiation on the composition of the fractions of serum protein by means of electrophoretic analysis (3-6). These studies revealed that the whole-body X-irradiation of either rats or rabbits resulted in a slight reduction of albumin 2 or 3 days after exposure. In addition, aand P-globulins were increased, whereas -y-globulin was pronouncedly decreased in the irradiated animals. Similar changes also occur in other diseases, as we have found, for example, in the case of Walker carcinoma of rats (7). A striking difference was noted, however. A considerable
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Winkler et al. (1956) studied this question.
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