Why the study?
Does intrathecal morphine reduce infarct size in a rat model of ischemia-reperfusion injury?
Population
35 barbiturate-anesthetized, open-chested, Wistar rats with chronic indwelling thoracic intrathecal…
Comparison
Intrathecal morphine administered 20 min before… vs Intrathecal 0.9% saline or IV morphine plus IT…
Design
Preclinical, randomly assigned
Follow-up
90 min of reperfusion
Authors
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Intrathecal morphine may confer cardioprotection in rats; hypothesis-generating and should not yet change clinical practice.
Does intrathecal morphine reduce infarct size in a rat model of ischemia-reperfusion injury?
Very small doses of intrathecal morphine reduce infarct size in a rat model of ischemia-reperfusion injury to a similar extent as larger doses of IV morphine.
Groban et al. (2004) studied this question.
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