Why the study?
Does large-dose intrathecal morphine reduce postoperative analgesic requirements and blood catecholamine levels in patients undergoing coronary artery bypass grafting?
Population
Patients undergoing coronary artery bypass grafting (cardiac surgery)
Comparison
Intrathecal morphine 4.0 mg vs Intrathecal saline placebo; both groups received…
Design
RCT, Randomized
Follow-up
Immediate postoperative period
Authors
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Intrathecal morphine reduces postoperative opioid needs after CABG; confirms analgesia benefit without attenuating catecholamine response.
Does large-dose intrathecal morphine reduce postoperative analgesic requirements and blood catecholamine levels in patients undergoing coronary artery bypass grafting?
Large-dose intrathecal morphine provides reliable postoperative analgesia but does not significantly attenuate the stress response (catecholamine levels) during and after cardiac surgery.
Chaney et al. (1996) studied this question.
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