Key result
Intrathecal morphine significantly prolonged the mean time to extubation compared to placebo (10.9 h vs 7.6 h) in patients undergoing cardiac surgery.
Why the study?
Does intrathecal morphine improve early tracheal extubation and reduce postoperative analgesic requirements in patients undergoing cardiac surgery?
Population
40 patients undergoing cardiac surgery (coronary artery bypass grafting).
Comparison
Intrathecal morphine 10 micro g/kg. vs Intrathecal placebo. Both groups received…
Design
RCT, Randomized, Double-blinded, placebo-controlled
Follow-up
48 hours
Authors
Loading...
May hinder fast-track extubation protocols without reducing opioid needs; challenges routine use in cardiac surgery.
RCT (n=40)
Double-blind
randomized
Does intrathecal morphine improve early tracheal extubation and reduce postoperative analgesic requirements in patients undergoing cardiac surgery?
Absolute Event Rate: 10.9% vs 7.6%
Intrathecal morphine at 10 mcg/kg significantly delayed early tracheal extubation without significantly reducing 48-hour postoperative IV morphine requirements in cardiac surgery patients.
Chaney et al. (1997) conducted an RCT in Cardiac surgery (n=40). Intrathecal morphine vs. Intrathecal placebo was evaluated on Mean time from intensive care unit arrival to extubation. Intrathecal morphine significantly prolonged the mean time to extubation compared to placebo (10.9 h vs 7.6 h) in patients undergoing cardiac surgery.
Synapse has enriched 3 closely related papers on similar clinical questions. Consider them for comparative context: