Key result
Intrathecal morphine administration in major abdominal and thoracic surgery was safe, with no cases of respiratory depression, a 2.07% incidence of atelectasis, and a 1.86% need for respiratory support.
Why the study?
Optimal postoperative pain control accelerates recovery after major surgery, and this study aimed to establish the safety of intrathecal morphine regarding respiratory complications and their association with underlying comorbidities.
Is intrathecal morphine safe in terms of respiratory complications for patients undergoing major abdominal and thoracic surgery?
Population
484 patients undergoing major abdominal or thoracic surgical procedures
Comparison
Intrathecal morphine administration across surgical types
Design
Retrospective observational study
Follow-up
90 days
Authors
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May support respiratory safety of intrathecal morphine in major surgery; extends observational data but leaves open need for RCTs.
Observational (n=484)
No
Is intrathecal morphine safe in terms of respiratory complications for patients undergoing major abdominal and thoracic surgery?
Intrathecal morphine is a safe technique for acute postoperative pain management in major abdominal and thoracic surgery, with no observed cases of respiratory depression.
González et al. (2025) conducted an observational in Major abdominal and thoracic surgery (n=484). Intrathecal morphine was evaluated on Incidence of early and late respiratory depression. Intrathecal morphine administration in major abdominal and thoracic surgery was safe, with no cases of respiratory depression, a 2.07% incidence of atelectasis, and a 1.86% need for respiratory support.
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