Clinical Mutations in Lymphoblastomas

For years a group of diseases, now generally classed as lymphoblastomas, have been studied and interpreted as separate and distinct entities. This group comprises chiefly mycosis fungoides, Hodgkin's disease, lymphatic leukemia, lymphosarcoma and the subvarieties of these. Not only were these conditions considered quite separate one from another but there existed a wide difference of opinion regarding the interpretation of the clinical and pathologic changes in any one particular member of this group. To complicate an already chaotic state of affairs, cases appeared from time to time that possessed features of two or more of these diseases. Adding to this the widely varied and multiform lesions presented by any one condition made the confusion complete. In recent years a semblance of order has emerged from the chaos with the growth of the view that these conditions are all genetically related neoplasms involving the lymphoid tissues. One of us 1 has