Why the study?
Preoperative anxiety and pain in children and adolescents are associated with postoperative complications, and pharmacological premedical treatment beyond oral midazolam may be needed.
The choice of premedical treatment for children prior to procedures depends on the individual, situation, and staff preferences, with several alternatives to traditional oral midazolam available.
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Individualized premedical regimens may optimize pediatric anxiety control; leaves open optimal agent combinations and formulations.
Preoperative anxiety and pain in children and adolescents are associated with postoperative complications. Despite relevant non-pharmacological treatment, the addition of premedical treatment may be needed. Traditionally, oral midazolam has been a favourite premedical treatment. However, several alternatives are available. Additionally, simultaneous administration of the medications to achieve synergy may be advantable. The choice of premedical treatment and method of administration depends on the individual child, the situation, and the preferences of the medical staff.
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Holst et al. (2025) studied this question.
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