Biologically Driven Synthesis of Pyrazolo[3,4-d]pyrimidines As Protein Kinase Inhibitors: An Old Scaffold As a New Tool for Medicinal Chemistry and Chemical Biology Studies

Nitrogen-containing heterocycles are widely distributed in and essential for life, playing a vital role in the of all living cells. Among the many nitrogencontaining, the pyrazolo[3,4-d]pyrimidine nucleus(Figure 1) is an important drug-like scaffold that is present in pharmacologically active compounds. This review describes the synthesis of pyrazolo-pyrimidines and their activities as kinase inhibitors.