What question did this study set out to answer?

To assess how early versus delayed enteral feeding impacts pituitary, thyroidal, gonadal, and adrenal endocrine function in intensive care patients with traumatic brain injury.

September 30, 2011Journal of Parenteral and Enteral Nutrition

Effect of Early Compared With Delayed Enteral Nutrition on Endocrine Function in Patients With Traumatic Brain Injury

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To assess how early versus delayed enteral feeding impacts pituitary, thyroidal, gonadal, and adrenal endocrine function in intensive care patients with traumatic brain injury.
Conducted a prospective, open-label, randomized trial in intensive care unit patients with traumatic brain injury.
Allocated 34 patients to early enteral feeding (within 24–48 hours) and 25 patients to standard delayed enteral feeding.
Evaluated pituitary, thyroid, gonadal, and adrenal hormone levels on days 6 and 12 following hospital admission.
Delayed enteral feeding led to marked decreases in thyroid-stimulating hormone, free triiodothyronine, free thyroxine, and male testosterone relative to admission, whereas early feeding attenuated these declines.
Cortisol concentrations rose in the delayed feeding arm, but showed less pronounced increases in the early feeding group.
Mortality during the study occurred in 2 of 25 patients in the delayed feeding arm and 3 of 34 patients in the early feeding arm.

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Implication

Randomized trial reveals improved hormone stability with early enteral nutrition in traumatic brain injury patients, indicating potential clinical benefits over delayed feeding.

Cite This Study

Kraus et al. (2011) studied this question.

synapsesocial.com/papers/6a851a1b045f75bf5ef11e89 https://doi.org/10.1177/0148607110397878

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Implication

Randomized trial reveals improved hormone stability with early enteral nutrition in traumatic brain injury patients, indicating potential clinical benefits over delayed feeding.

Effect of Early Compared With Delayed Enteral Nutrition on Endocrine Function in Patients With Traumatic Brain Injury

Key Points

Discussion

Implication

Cite This Study

Effect of Early Compared With Delayed Enteral Nutrition on Endocrine Function in Patients With Traumatic Brain Injury

Key Points

Discussion

Implication

Cite This Study

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