An Intrafamilial Epidemic of Pharyngoconjunctival Fever

Pharyngoconjunctival fever has become recently recognized as a specific viral disease entity characterized by fever, pharyngitis, and conjunctivitis occurring singly or in combination, in epidemic or sporadic form. 1-3 Virus-isolation studies and the subsequent development and application of APC group-specific complement-fixation and type-specific neutralization tests have shown that APC Type 3 virus is the etiologic agent. 1-4 Epidemics have been reported from widely separated areas. 2-5 Since this disease entity may be confused with a variety of other infections or may be mild enough not to require the services of a physician, many cases are probably not recognized or reported. It is the purpose of this study to describe the disease as it appeared in a family of seven. Report of Cases Case 1. —A 12-year-old white boy was admitted to the Ohio State University Hospital on July 16, 1955, because of a six-day illness, characterized by pharyngitis, unilateral conjunctivitis,