Why the study?
Does enoxaparin or warfarin improve cost-effectiveness and prevent death compared to no prophylaxis in patients over 40 years old undergoing total knee replacement or knee arthroplasty?
Population
Cohort of 42,692 patients over 40 years old who underwent total knee replacement or knee arthroplasty, with…
Comparison
Enoxaparin or warfarin vs No prophylaxis
Design
Cohort
Authors
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May support enoxaparin over warfarin for VTE prophylaxis after TKR on cost and mortality grounds; leaves open confirmation in randomized trials.
Does enoxaparin or warfarin improve cost-effectiveness and prevent death compared to no prophylaxis in patients over 40 years old undergoing total knee replacement or knee arthroplasty?
In patients undergoing total knee replacement, pharmacological VTE prophylaxis with enoxaparin is highly cost-effective and prevents more deaths compared to warfarin or no prophylaxis.
Nerurkar et al. (2002) studied this question.
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