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When quinic acid is given orally to man and to guinea pigs, it is aromatized and appears in urine as hippuric acid. Neomycin, in doses sufficient to inhibit bacterial multiplication in the intestinal tract, prevents conversion of quinic to hippuric acid in man. When quinic acid is given parenterally to guinea pigs, it is not converted to hippuric acid. It is concluded that aromatization of quinic acid in man and in guinea pig is achieved by intestinal bacteria.
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Cotran et al. (1960) studied this question.
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