Answers are grounded in this paper and cite their sources.
The expedient synthesis of tricyclic and tetracyclic compounds via a cascade polycyclization methodology is described. Nazarov substrates (II) containing two Michael acceptors and a cyclohexenone ester (I) underwent cycloaddition followed by intramolecular 1,4-addition to furnish, in a highly stereoselective manner, tricyclic and tetracyclic products (III). Such compounds are interesting intermediates for the synthesis of polycyclic natural and unnatural products.
No takes yet. Share an insight, caveat, or question.
Guay et al. (2003) studied this question.
Synapse has enriched 10 related papers. Consider them for comparative context: