July 4, 1990JAMA

Cost-effectiveness of Misoprostol for Prophylaxis Against Nonsteroidal Anti-inflammatory Drug—Induced Gastrointestinal Tract Bleeding

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Why the study?

Is misoprostol cost-effective for the prevention of NSAID-induced gastrointestinal tract bleeding in various patient populations?

Population

NSAID users

Comparison

1-year course of misoprostol as primary or… vs No misoprostol

Follow-up

1 year (modeled)

Authors

JEJonathan T. EdelsonShimane University

Discussion

Member takes

Implication

Should not change practice for primary prevention; leaves open targeted secondary prevention pending prospective validation.

Structured PICO

Is misoprostol cost-effective for the prevention of NSAID-induced gastrointestinal tract bleeding in various patient populations?

Population

NSAID users (analyzed as three groups: all users, users aged 60 years or older, and users with rheumatoid arthritis)

Intervention

1-year course of misoprostol as primary or secondary prevention

Comparator

No misoprostol (implied by incremental cost-effectiveness ratio)

Outcome

Incremental cost-effectiveness ratio (cost per year of life saved)

Misoprostol is not cost-effective as primary prevention for NSAID-induced GI bleeding but may be cost-effective as secondary prevention in patients with a prior history of bleeding.

Cite This Study

Jonathan T. Edelson (1990) studied this question.

synapsesocial.com/papers/6a8520209df997f4bbd69d93 https://doi.org/10.1001/jama.1990.03450010045028

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Bookmark

Cost-effectiveness of Misoprostol for Prophylaxis Against Nonsteroidal Anti-inflammatory Drug—Induced Gastrointestinal Tract Bleeding

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Cost-effectiveness of Misoprostol for Prophylaxis Against Nonsteroidal Anti-inflammatory Drug—Induced Gastrointestinal Tract Bleeding

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider