Quantized Current Blockade and Hydrodynamic Correlations in Biopolymer Translocation through Nanopores: Evidence from Multiscale Simulations

We present a detailed description of biopolymer translocation through a nanopore in the presence of a solvent using an innovative multiscale methodology that treats the biopolymer at the microscopic scale as combined with a self-consistent mesoscopic description for the solvent fluid dynamics. We report evidence for quantized current blockade depending on the folding configuration and offer detailed information on the role of hydrodynamic correlations in speeding up the translocation process.