Key result
Major non-ischaemic myocardial fibrosis is linked to ~220% higher risk of death or HF hospitalization.
Why the study?
Non-ischaemic cardiomyopathies can cause heart failure and death, but the prevalence and prognosis of ischaemic versus non-ischaemic myocardial fibrosis in older community-based adults were not established.
Does the presence of non-ischaemic myocardial fibrosis on CMR predict death or heart failure hospitalization in older adults without pre-existing heart failure?
Cohort (n=900)
Does the presence of non-ischaemic myocardial fibrosis on CMR predict death or heart failure hospitalization in older adults without pre-existing heart failure?
Hazard Ratio: 3.2
p-value: p=<0.001
Major non-ischaemic patterns of myocardial fibrosis on CMR portend a significantly worse prognosis for death or heart failure hospitalization than no fibrosis or even ischemic scar in older adults.
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Non-ischaemic LGE may refine prognosis in older adults; leaves open whether detection should alter management.
Shanbhag et al. (2018) conducted a cohort in Myocardial fibrosis (n=900). Major non-ischaemic myocardial fibrosis vs. No late gadolinium enhancement (no fibrosis) was evaluated on Time to death or first heart failure hospitalization (HR 3.2, p=<0.001). Major non-ischaemic myocardial fibrosis was independently associated with a higher risk of death or heart failure hospitalization (HR 3.2, P<0.001).
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