Thyrotropin-releasing hormone and phorbol esters induce phosphatidylcholine synthesis in GH3 pituitary cells. Evidence for stimulation via protein kinase C.

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Population

GH3 pituitary cells

Comparison

12-O-tetradecanoylphorbol 13-acetate and… vs Control

Design

Preclinical

Follow-up

up to 30 minutes

Authors

Discussion

May implicate PKC in TRH effects on pituitary cell lipids; leaves open relevance to human physiology or therapy.

Population

GH3 pituitary cells

Intervention

12-O-tetradecanoylphorbol 13-acetate (TPA) and thyrotropin-releasing hormone (TRH)

Comparator

Control

Outcome

Phosphatidylcholine synthesis (incorporation of 32Pi and [3H]choline) and choline-phosphate cytidylyltransferase activitysurrogate

Hormones such as TRH may regulate phosphatidylcholine metabolism via the protein kinase C pathway in GH3 pituitary cells.

Richard Kolesnick (1987) studied this question.

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