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January 1, 2006Eukaryotic CellOpen Access

RNAi knockdown of alpha and beta subunits decreased oligomycin-sensitive ATP hydrolytic and synthetic activities by 43% and 44%, respectively, and significantly decreased mitochondrial membrane potential compared to wild-type cells.

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Population

Bloodstream form Trypanosoma brucei cells

Comparison

RNA interference targeting the F1-ATPase alpha… vs Uninduced (wild-type) cells

Design

Preclinical

Authors

SBSilvia V. BrownPHPaul HoskingJLJinlei Li

Discussion

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Overview

Supports ATP synthase as antiparasitic target in T. brucei; leaves open translation to clinical efficacy.

Structured PICO

P
Population
Bloodstream form Trypanosoma brucei cells
I
Intervention
RNA interference (RNAi) targeting the F1-ATPase alpha and beta subunits
C
Comparator
Uninduced (wild-type) cells
O
Outcome
Mitochondrial membrane potentialsurrogate

ATP synthase is essential for maintaining the mitochondrial membrane potential in the bloodstream form of Trypanosoma brucei.

Cite This Study

Brown et al. (2006) studied this question.

synapsesocial.com/papers/6a8521264edd3eca19cf1fe7https://doi.org/10.1128/ec.5.1.45-53.2006
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