What question did this study set out to answer?

To assess the therapeutic capacity of Dillenia indica methanolic fruit extract in reducing hyperglycemia-induced oxidative stress and apoptosis in the liver and kidney tissues of diabetic mice.

May 26, 2023Frontiers in Bioscience-LandmarkOpen Access

Therapeutic Potential of Dillenia indica L. in Attenuating Hyperglycemia-Induced Oxidative Stress and Apoptosis in Alloxan-Administered Diabetic Mice

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Authors

PSPlabita Sahariah JBJutishna BoraCzech Academy of Sciences, Institute of Biotechnology SMSumira MalikChandigarh University

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Implication

Preclinical study reveals Dillenia indica fruit extract reduces oxidative damage and apoptosis in diabetic mice, indicating therapeutic potential against diabetes-induced tissue injury.

Key Points

To assess the therapeutic capacity of Dillenia indica methanolic fruit extract in reducing hyperglycemia-induced oxidative stress and apoptosis in the liver and kidney tissues of diabetic mice.
Characterized Dillenia indica methanolic fruit extract (MFE) via High-Performance Thin Layer Chromatography (HPTLC) to identify antioxidant constituents.
Administered MFE to alloxan-induced diabetic mice and measured GLUT4 expression, lipid peroxidation via malondialdehyde (MDA) levels, and cellular ultrastructural changes in liver and kidney tissues.
Assessed apoptosis in diabetic tissues using TUNEL assays and measured protein expression levels of caspase-3 and Bcl-2.
HPTLC profiling identified the presence of key antioxidant compounds, specifically ascorbic acid and naringenin.
MFE administration upregulated GLUT4 expression, decreased MDA levels, and reversed cellular ultrastructural abnormalities in diabetic liver and kidney tissues.
MFE treatment reduced TUNEL-positive apoptotic cells, downregulated caspase-3 expression, and upregulated anti-apoptotic Bcl-2 expression relative to untreated diabetic controls.

Cite This Study

Sahariah et al. (2023) studied this question.

synapsesocial.com/papers/6a85219c404dce2ee642e95b https://doi.org/10.31083/j.fbl2805105

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Implication

Preclinical study reveals Dillenia indica fruit extract reduces oxidative damage and apoptosis in diabetic mice, indicating therapeutic potential against diabetes-induced tissue injury.

Therapeutic Potential of Dillenia indica L. in Attenuating Hyperglycemia-Induced Oxidative Stress and Apoptosis in Alloxan-Administered Diabetic Mice

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Implication

Key Points

Cite This Study

Therapeutic Potential of Dillenia indica L. in Attenuating Hyperglycemia-Induced Oxidative Stress and Apoptosis in Alloxan-Administered Diabetic Mice

Discussion

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Implication

Key Points

Cite This Study

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