Venlafaxine withdrawal can cause severe electric shock-like sensations, similar to SSRI discontinuation.
Venlafaxine tapering may provoke severe shock-like sensations; case report leaves open incidence, risk factors, and optimal management.
Electric shock-like sensations may occur after cessation of treatment with serotonin selective reuptake inhibitors but are reported in the literature only rarely with discontinuation of venlafaxine. Two patients experienced severe shock-like sensations during venlafaxine withdrawal. For both patients symptoms occurred with lowering of the dosage and persisted for 5 days after complete discontinuation of the drug. These sensations may represent significant alteration of neuronal activity in the central nervous system.
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Reeves et al. (2003) studied this question.
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