Late-onset granuloma formation after poly-l-lactic acid injection

This is the authors' abstract. We don't add key points for this paper.

Poly-l-lactic acid (Sculptra, Sanofi Aventis, Bridgewater, NJ) is a gel polymer made of poly-l-lactic acid microspheres and water suspended in a mannitol and carboxymethyl cellulose suspension.1 This injectable tissue filler has been used for correction of lipoatrophy in HIV patients as well as for cosmetic purposes since its US Food and Drug Administration approval in 2004. The mechanism of action involves induction of a subclinical inflammatory response that stimulates fibroblast proliferation and collagen formation, ultimately leading to a progressive increase in volume of the dermis and subcutaneous tissues.