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No form of treatment has been demonstrated to alter the long-term course of multiple sclerosis. This is not because of lack of effort. From Charcot's time up to the present issue of the Journal,1 , 2 trials of hundreds of various treatments have been reported. A synopsis of the 120 therapeutic claims involving the disease was published last year by the International Federation of Multiple Sclerosis Societies.3 Only one substance, ACTH, has been shown in a controlled double-blind trial to shorten the duration of acute attacks of multiple sclerosis.4 Many physicians believe that steroids are equally effective, but this has not . . .
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Dale E. McFarlin (1983) studied this question.
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