Population
161 individuals in 26 kindreds investigated for familial hyper-alpha-lipoproteinemia
Design
Cross-sectional
Authors
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May indicate ancestry-specific genetic effects on HDL-C; hypothesis-generating and requires replication before influencing screening or therapy.
Familial hyper-alpha-lipoproteinemia may be driven by a major gene effect in white populations, as evidenced by a bimodal distribution of HDL-C.
Siervogel et al. (1980) studied this question.
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