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Extra-PV drivers in persistent AF merit targeted study; leaves open whether they improve ablation outcomes.
Atrial fibrillation (AF) is a sustained cardiac arrhythmia whose drivers and mechanisms are complex and incompletely understood. The most current estimates predict that up to 12 million people in the US will be affected by 2050 1. Pulmonary vein isolation (PVI) is the cornerstone of treatment for paroxysmal AF, but has lower efficacy in persistent atrial fibrillation, where the drivers perpetuating AF often lie outside the pulmonary veins (PV)2–4.
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Manongi et al. (2023) studied this question.
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