Why the study?
In persistent AF, identifying clinically significant nonpulmonary vein targets and achieving durability of ablation lesions remains an important challenge.
Pulmonary vein isolation is the cornerstone of ablation for persistent atrial fibrillation, though identifying nonpulmonary vein targets and ensuring lesion durability remain key challenges.
Challenges in non-PV targeting and lesion durability warrant targeted trials; leaves open refined ablation strategies for persistent AF.
Atrial Fibrillation (AF) is the most common form of electrical disturbance of the heart and contributes to significant patient morbidity and mortality. With a better understanding of the mechanisms of atrial fibrillation and improvements in mapping and ablation technologies, ablation has become a preferred therapy for patients with symptomatic AF. Pulmonary Vein Isolation (PVI) is the cornerstone for AF ablation therapy, but particularly in patients with AF occurring for longer than 7 days (persistent AF), identifying clinically significant nonpulmonary vein targets and achieving durability of ablation lesions remains an important challenge.
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Ifedili et al. (2021) studied this question.
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