Why the study?
ICDs reduce mortality in monomorphic VT by preventing sudden death, but have no effect on the arrhythmogenic substrate and only address symptom control.
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Design
Single center study
May support radiation therapy for refractory VT; hypothesis-generating and leaves open need for randomized trials before practice change.
Ventricular tachycardia (VT) is a potentially life-threatening arrhythmia characterized by electrical re-entry within patches of heterogeneous myocardial fibrosis leading to sustained consecutive ventricular beats at a rate >100/min.1 In patients with monomorphic VT, implantable cardioverter-defibrillators (ICD) have become the cornerstone of therapy in decreasing mortality through the prevention of sudden death.2 However, ICDs have no effect on the arrhythmogenic substrate and address symptom-control only.
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Gerard et al. (2021) studied this question.
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