Why the study?
Zhenwu Decoction can improve left ventricular ejection fraction and reduce cardiac hypertrophy in chronic heart failure, but its underlying pharmacological mechanism remains unclear.
Does Zhenwu Decoction ameliorate cardiac hypertrophy in preclinical models?
Population
Zebrafish and animal models of cardiac hypertrophy
Comparison
Zhenwu Decoction vs controls or sGC inhibitor ODQ
Design
Preclinical network pharmacology, mechanistic, and animal study
Authors
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Hypothesis-generating for Zhenwu Decoction in hypertrophy; leaves open translation beyond zebrafish models.
Does Zhenwu Decoction ameliorate cardiac hypertrophy in preclinical models?
Zhenwu Decoction exerts cardioprotective effects against cardiac hypertrophy by activating the sGC-cGMP-PKG signaling pathway in preclinical models.
Chen et al. (2022) studied this question.
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