Why the study?
Evidence comparing the performance of different pentaspline catheter sizes for pulsed-field ablation remains limited, as previous studies largely pooled 31-mm and 35-mm catheters without dedicated analyses.
Does the 31-mm pentaspline PFA catheter improve procedural characteristics, safety, and clinical outcomes compared to the 35-mm catheter in patients undergoing PVI for atrial fibrillation?
Does the 31-mm pentaspline PFA catheter improve procedural characteristics, safety, and clinical outcomes compared to the 35-mm catheter in patients undergoing PVI for atrial fibrillation?
Comparative study assesses procedural performance and safety across catheter sizes in atrial fibrillation, indicating key factors for device selection.
Pulsed-field ablation (PFA) using a pentaspline catheter has rapidly emerged as an effective and safe approach for pulmonary vein isolation (PVI).1,2 However, evidence comparing the performance of different pentaspline catheter sizes remains limited, as previous studies largely pooled 31-mm and 35-mm catheters without dedicated analyses.2–4 We therefore compared procedural characteristics, safety, and clinical outcomes between the 31-mm and 35-mm pentaspline PFA catheters in patients undergoing PVI for atrial fibrillation (AF).
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Isenegger et al. (2026) studied this question.
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