Caveolin-1 expression is significantly increased during macrophage apoptosis and may facilitate the externalization of phosphatidylserine, which is relevant for the clearance of aged cells and atherosclerotic lesion stability.
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Hypothesis-generating for caveolin-1 in macrophage apoptosis; leaves open its role in efferocytosis and plaque stability.
Gargalovic et al. (2003) studied this question.
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