Cardiovascular magnetic resonance‐GUIDEd management of mild to moderate left ventricular systolic dysfunction (CMR GUIDE): Study protocol for a randomized controlled trial
Why the study?
Does a primary prevention ICD reduce sudden cardiac death or hemodynamically significant ventricular arrhythmia in patients with mild-moderate LV systolic dysfunction and CMR evidence of fibrosis?
Population
Patients with mild-moderate left ventricular systolic dysfunction and CMR evidence of fibrosis on optimal…
Comparison
Primary prevention implantable cardiac… vs Implantable loop recorder (ILR)
Design
Other, Randomized to receive either a primary prevention ICD or an implantable…
Follow-up
average 4-year
Authors
Discussion
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Member takes
Implication
Evidence for CMR-guided ICDs in mild-moderate LV dysfunction with fibrosis remains lacking; CMR GUIDE will deliver needed randomized data.
Structured PICO
Does a primary prevention ICD reduce sudden cardiac death or hemodynamically significant ventricular arrhythmia in patients with mild-moderate LV systolic dysfunction and CMR evidence of fibrosis?
P
Population
Patients with mild-moderate left ventricular (LV) systolic dysfunction (LVEF 36-50%) and CMR evidence of fibrosis on optimal heart failure therapy
I
Intervention
Primary prevention implantable cardiac defibrillator (ICD)
C
Comparator
Implantable loop recorder (ILR)
O
Outcome
Time to sudden cardiac death (SCD) or hemodynamically significant ventricular arrhythmia (VF or VT) during an average 4-year follow-upcomposite
The CMR GUIDE trial protocol outlines a study to determine if CMR-guided ICD insertion improves survival in patients with mild-moderate LV systolic dysfunction and myocardial fibrosis.
Cite This Study
Selvanayagam et al. (2017) studied this question.