Population
Cultured neonatal rat cardiac myocytes and Bio14.6 Syrian cardiomyopathic hamsters
Comparison
Phenylephrine stimulation and specific ECE-1… vs Saline stimulation
Design
Preclinical
Authors
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Implicates ECE-1 in rat myocyte hypertrophy; hypothesis-generating and leaves open in vivo and human relevance.
The conversion of big ET-1 to ET-1 by ECE-1 is required for alpha1-adrenergic-stimulated hypertrophy and beta-myosin heavy chain gene transcription in rat cardiac myocytes.
Kaburagi et al. (1999) studied this question.
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