What question did this study set out to answer?

To investigate the association between systemic medications that alter bone metabolism and the subsequent risk of dental implant failure.

October 1, 2018Clinical Oral Implants ResearchOpen Access

Medication‐related dental implant failure: Systematic review and meta‐analysis

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Authors

VCVivianne ChappuisUniversity of Bern GÁGustavo Ávila‐OrtizUniversity of Michigan MAMaurício G. AraújoUniversidade Estadual de Maringá

Discussion

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Implication

Systematic review and meta-analysis reveals increased dental implant failure rates with proton pump inhibitors and selective serotonin reuptake inhibitors, highlighting medication-related risks.

Key Points

To investigate the association between systemic medications that alter bone metabolism and the subsequent risk of dental implant failure.
Conducted electronic and manual literature searches, identifying 17 studies evaluating bisphosphonates (n=7), non-steroidal anti-inflammatory drugs (n=5), proton pump inhibitors (n=2), selective serotonin reuptake inhibitors (n=2), and antihypertensives (n=1).
Evaluated dental implant failure as the primary binary endpoint using meta-analyses to estimate odds ratios and risk differences.
Proton pump inhibitor (PPI) use was associated with a statistically significant 4.3% increase in implant failure rates compared with controls (p < 0.5).
Selective serotonin reuptake inhibitor (SSRI) use was associated with a statistically significant 7.5% increase in implant failure rates compared with controls (p < 0.5).
Bisphosphonates and NSAIDs showed no statistically significant impact on implant failure, whereas a single study indicated improved implant survival with antihypertensive drugs.

Cite This Study

Chappuis et al. (2018) studied this question.

synapsesocial.com/papers/6a85352a385dd211e7c2a917 https://doi.org/10.1111/clr.13137

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Implication

Systematic review and meta-analysis reveals increased dental implant failure rates with proton pump inhibitors and selective serotonin reuptake inhibitors, highlighting medication-related risks.

Medication‐related dental implant failure: Systematic review and meta‐analysis

Discussion

Member takes

Implication

Key Points

Cite This Study

Medication‐related dental implant failure: Systematic review and meta‐analysis

Discussion

Member takes

Implication

Key Points

Cite This Study

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