Why the study?
The direct effect of enteroviral protease 2A in enteroviral cardiomyopathy was unclear because other viral proteins are also expressed during infection.
Does inducible cardiac-restricted expression of enteroviral protease 2A induce dilated cardiomyopathy in transgenic mice?
Population
Transgenic mice with inducible cardiac-restricted expression of enteroviral protease 2A and cultured myocytes isolated from these mice
Comparison
Tamoxifen-treated 2AxMCM mice vs 2AxMCM mice treated with tamoxifen diluent and tamoxifen-treated MCM littermates
Design
Preclinical study using tamoxifen-regulated Cre-loxP system in transgenic mice
Authors
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Does not inform clinical care; leaves open whether enteroviral protease 2A contributes to human dilated cardiomyopathy.
Does inducible cardiac-restricted expression of enteroviral protease 2A induce dilated cardiomyopathy in transgenic mice?
Enteroviral protease 2A alone is sufficient to induce dilated cardiomyopathy, associated with sarcolemmal membrane disruption and dystrophin cleavage.
Xiong et al. (2006) studied this question.
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