This autopsy case of Brugada syndrome highlights significant structural abnormalities, including marked fatty tissue deposition in the right ventricular outflow tract and severe fibroadipose lesions in the sinus node.
Does not alter Brugada management; leaves open whether fibrofatty lesions are causal or generalizable.
A 30-year-old man with Brugada syndrome died suddenly. The heart weighed 380 g. The left ventricular wall showed mild thickening, and marked fatty tissue deposition was noted in the right ventricular outflow tract. Neither ventricle was enlarged. Contraction band necrosis was diffuse in both ventricles. In the ventricles no cardiac muscle cell hypertrophy or atrophy, or significant interstitial fibrosis was observed. In the sinus node the number of nodal cells was reduced by half, with fatty tissue and fibrosis prominent. But no lesions were evident in the right bundle branch.
No takes yet. Share an insight, caveat, or question.
Morimoto et al. (2005) studied this question.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: