March 30, 2001Circulation ResearchOpen Access

Functional Roles of Cardiac and Vascular ATP-Sensitive Potassium Channels Clarified by Kir6.2-Knockout Mice

View Full Paper

Ask AI

Bookmark

Population

Kir6.2-deficient mice and Kir6.2 mice, including ventricular cells, neonatal ventricular cells, aortas, and…

Comparison

Pharmacological K channel openers and gene… vs Wild-type mice/cells and baseline conditions…

Design

Preclinical

Authors

MSMasashi SuzukiOtsuma Women's University

Discussion

Member takes

Implication

Kir6.2-dependent cardiac effects of K(+) channel openers may enable selective targeting; leaves open translation to human therapies.

Structured PICO

Population

Kir6.2-deficient (knockout [KO]) mice and Kir6.2(+/+) (wild-type [WT]) mice, including ventricular cells, neonatal ventricular cells, aortas, and aortic smooth muscle cells

Intervention

Pharmacological K(+) channel openers (pinacidil, P-1075, and diazoxide) and gene transfer of Kir6.2

Comparator

Wild-type mice/cells and baseline conditions without K(+) channel openers

Outcome

Electrophysiological responses (sarcolemmal K(ATP) channel currents, action potential shortening) and contractile function (force generation, relaxation, hypotension)surrogate

The Kir6.2 subunit mediates the depression of cardiac excitability and contractility induced by K(+) channel openers, but plays no discernible role in the arterial tree.

Cite This Study

Masashi Suzuki (2001) studied this question.

synapsesocial.com/papers/6a853850b6c67ec53fcf286f https://doi.org/10.1161/01.res.88.6.570

View Full Paper

Ask AI

Bookmark

Functional Roles of Cardiac and Vascular ATP-Sensitive Potassium Channels Clarified by Kir6.2-Knockout Mice

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Functional Roles of Cardiac and Vascular ATP-Sensitive Potassium Channels Clarified by Kir6.2-Knockout Mice

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider