Correctable Intestinal Defect of Vitamin B₁₂ Absorption in Pernicious Anemia

Article1 December 1967Correctable Intestinal Defect of Vitamin B12 Absorption in Pernicious AnemiaRALPH CARMEL, M.D., VICTOR HERBERT, M.D.RALPH CARMEL, M.D., VICTOR HERBERT, M.D.Author, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-67-6-1201 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptIntestinal absorptive defects have been reported in patients with pernicious anemia (1). Malabsorption of vitamin B12due to a defect in the ileum has also been noted, and several instances of correction by therapy of this B12malabsorption have been reported in pernicious anemia (2-4) and in idiopathic steatorrhea (5). In this study we evaluated ten successive patients with pernicious anemia, found an ileal defect in absorption of B12in four of them, and corrected the B12malabsorption by B12therapy in three of these four. The true incidence of a gross intestinal defect in absorption of B12in patients...References1. BEZMANKINNEARZAMCHECK ADGN: D-xylose and potassium iodide absorption and serum carotene in pernicious anemia. J. Lab. Clin. Med. 53: 226, 1959. MedlineGoogle Scholar2. HAURANISHERWOODGOLDSTEIN FIWF: Intestinal malabsorption of vitamin B12 in pernicious anemia. Metabolism 13: 1342, 1964. CrossrefMedlineGoogle Scholar3. BRODYESTRENHERBERT EASV: Coexistent pernicious anemia and malabsorption in four patients: including one whose malabsorption disappeared with vitamin B12 therapy. Ann. Intern. Med. 64: 1246, 1966. LinkGoogle Scholar4. LAMPKINMAUER BCAM: Congenital pernicious anemia with coexistent transitory intestinal malabsorption of vitamin B12. Blood 30: 495, 1967. CrossrefMedlineGoogle Scholar5. MOLLINBOOTHBAKER DLCLSJ: The absorption of vitamin B12 in control subjects, in Addisonian pernicious anemia and in the malabsorption syndrome. Brit. J. Haemat. 3: 412, 1957. 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Sci. 182: 741, 1931. CrossrefGoogle Scholar17. HERBERT V: Drugs effective in megaloblastic anemias, in The Pharmacological Basis of Therapeutics, 3rd ed., edited by GOODMAN, L. S., GILMAN, A. The Macmillan Co., New York, 1965, p. 1411. Google Scholar18. FOROOZANTRIER PJS: Mucosa of the small intestine in pernicious anemia. New Eng. J. Med. 277: 553, 1967. CrossrefMedlineGoogle Scholar19. SAULIASTALDIMALOSSINI SGL: Histopathology of intestinal mucosa obtained by Crosby's biopsy in pernicious anemia before and after vitamin B12 treatment. Acta Vitamin. (Milano) 17: 143, 1963. MedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: New York, New YorkFrom the Department of Hematology, The Mount Sinai Hospital and Medical School, New York, N. Y.This work was supported in part by grants AM 09564, AM 09062, and AM 11048, U. S. Public Health Service, Washington, D. C., and by the Albert A. List, Frederick Machlin, and Anna Ruth Lowenberg Funds, The Mount Sinai Hospital.Dr. Carmel was supported in this study by Postdoctoral Fellowship 5-F2AM-32518, U. S. Public Health Service, Washington, D. C., and Dr. Herbert was supported by Career Scientist Award I-435, Health Research Council of the City of New York.Requests for reprints should be addressed to Ralph Carmel, M.D., Department of Hematology, The Mount Sinai Hospital and Medical School, New York, N. Y. 10029. 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PEZZIMENTI, M.D., NANCY SHEA, B.S.Absorption of Water-Soluble VitaminsTrehalose Tolerance TestVitamin B12 Absorption and MalabsorptionSpecificity of the Correction of Vitamin B12 Malabsorption by Pancreatic Extract and its Clinical SignificanceVitamin B 12 Malabsorption Due to a Biologically Inert Intrinsic FactorDetection of malabsorption of vitamin B12 due to gastric or intestinal dysfunctionMorphology, Dipeptidases and Disaccharidases of Small Intestinal Mucosa in Vitamin B12 and Folic Acid DeficiencyTemperate sprue.Current Concepts of Iron Metabolism and the Iron Deficiency AnemiasVitamin B12 absorption in some neurological and neuroendocrine disordersAbsorption and malabsorption of vitamin B12Eosinophilic GastroenteritisFolic acid (3HFA) absorption and jejunal biopsy in mild nutritional folic acid deficiencyNuclear HematologyTRANSIENT (REVERSIBLE) MALABSORPTION OF VITAMIN B 12Effect of vitamin B12 and folic acid deficiency on small intestinal absorptionPseudotumor Cerebri Associated with Pernicious AnemiaTHOMAS E. MURPHY, JOHN J. COSTANZIMalabsorptionApplication of Whole Body Counting to the Measurement of Vitamin B 12 Absorption with Reference to AchlorhydriaMalabsorption in Pernicious AnemiaMUNSEY S. WHEBY, M.D., F.A.C.P.Studies on Two Patients with Concomitant Intrinsic Factor Secretory Defect and Jejunal DiverticulosisReduced Absorption of Vitamin B12 in Two Patients with Folic Acid DeficiencyROBERT B. SCOTT, M.D., F.A.C.P., ROBERT B. KAMMER, M.D., WILBUR F. BURGER, M.D., FRANCIS G. MIDDLETON, M.D. 1 December 1967Volume 67, Issue 6Page: 1201-1207KeywordsFellowshipsHematology and oncologyIleumMedical servicesPernicious anemiaScientists Issue Published: 1 December 1967 PDF downloadLoading ...