January 20, 1992FEBS Letters

Nitrendipine is a potent inhibitor of the Ca2+‐activated K+ channel of human erythrocytes

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Population

Human erythrocytes suspended in a solution with physiological Na+ and K+ concentrations

Design

Preclinical

Authors

JEJ. Clive ElloryUniversity of Jordan KKKiaran KirkAustralian National University SCS.J. CullifordUniversity of Bristol

Discussion

Member takes

Implication

May warrant caution for off-target erythrocyte effects; leaves open in vivo relevance and clinical translation.

Structured PICO

Population

Human erythrocytes suspended in a solution with physiological Na+ and K+ concentrations

Intervention

Nitrendipine

Outcome

Inhibition of K+(86Rb+) influx and effluxsurrogate

Nitrendipine is a potent inhibitor of the Ca2+-activated K+ channel in human erythrocytes, expanding its known pharmacological profile beyond L-type Ca2+ channel blockade.

Cite This Study

Ellory et al. (1992) studied this question.

synapsesocial.com/papers/6a8538d2f2bb7ee68cf23f43 https://doi.org/10.1016/0014-5793(92)80383-r

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Nitrendipine is a potent inhibitor of the Ca2+‐activated K+ channel of human erythrocytes

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Nitrendipine is a potent inhibitor of the Ca2+‐activated K+ channel of human erythrocytes

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider