What question did this study set out to answer?

To determine whether epidermal growth factor delays the onset of labor by preventing prepartum corpus luteum regression and to profile epidermal growth factor levels in amniotic fluid across gestation.

May 23, 2005Proceedings of the National Academy of SciencesOpen Access

Epidermal growth factor prevents prepartum luteolysis in the rat

View Full Paper

Ask AI

Bookmark

Authors

MRMaria L.C. RibeiroConsejo Nacional de Investigaciones Científicas y Técnicas JAJulieta AisembergUniversity of Buenos Aires SBSilvia BilliConsejo Nacional de Investigaciones Científicas y Técnicas

Discussion

Member takes

Implication

Laboratory study demonstrates intrauterine epidermal growth factor prevents corpus luteum regression in pregnant rats, indicating a mechanism for delayed labor onset.

Key Points

To determine whether epidermal growth factor delays the onset of labor by preventing prepartum corpus luteum regression and to profile epidermal growth factor levels in amniotic fluid across gestation.
Administered 500 ng of intrauterine epidermal growth factor to pregnant rats on day 21, evaluating outcomes across 0, 4, 8, 12, 24, and 48 hours post-treatment.
Measured amniotic fluid epidermal growth factor concentrations in control pregnant rats across gestation days 13 and 18 to 22.
Intrauterine epidermal growth factor reduced uterine prostaglandin F(2alpha) synthesis at 8 hours and rendered uterine cyclooxygenase 1 expression undetectable at 12 hours.
Serum progesterone reached peak concentrations 12 hours post-treatment, with corpora lutea morphology resembling peak day 13 gestation levels.
Amniotic fluid epidermal growth factor concentrations steadily increased during gestation, reached maximum levels on day 21, and declined immediately prior to labor.

Cite This Study

Ribeiro et al. (2005) studied this question.

synapsesocial.com/papers/6a8539df69a073149ac6b138 https://doi.org/10.1073/pnas.0502899102

View Full Paper

Ask AI

Bookmark

Implication

Laboratory study demonstrates intrauterine epidermal growth factor prevents corpus luteum regression in pregnant rats, indicating a mechanism for delayed labor onset.

Epidermal growth factor prevents prepartum luteolysis in the rat

Discussion

Member takes

Implication

Key Points

Cite This Study

Epidermal growth factor prevents prepartum luteolysis in the rat

Discussion

Member takes

Implication

Key Points

Cite This Study

Also Consider

Also Consider