Preparation of tubes with an internal nanotopography based on polymer de-mixing is presented. A solution of two polymers is quickly blown through a tube, forming a nanotopographic surface. The shape and feature size can be partially controlled. The Figure shows a 3D representation of the topography inside a glass tube measured using atomic force microscopy, clearly showing the curvature of the tube (image size: 15 μm × 15 μm).
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Gadegaard et al. (2004) studied this question.
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